MECHANISMS OF ACTION OF ALKALOIDS IN THE MANAGEMENT OF DIABETES MELLITUS

Abstract

The aim of the diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long term diabetic complications and, by eliminating various risk factors. The inability of current therapies to control all the metabolic defects of the disease and their pathological consequences, cost effect, there is a need for the alternative strategies for diabetes therapy. The mechanism of action of herbal antidiabetic could be; stimulation of insulin secretion from beta cells, reduction in insulin resistance, stimulation of glycogenesis and hepatic glycolysis, activation of PPAR γ, etc. This review summarizes the specific mechanism action of different alkaloids that target the various metabolic pathways in human body.