Studies on the constituents of Cimicifuga species. XIX. Eight new glycosides from Cimicifuga simplex Wormsk.

Abstract

Eight new glycosides were isolated from Cimicifuga simplex (Ranunculaceae), and their structures were determined to be 23-O-acetyl-7,8- didehydroshengmanol-3-O-α-L-arabinopyranoside (1), 24-epi-24-O-acetyl-7,8- didehydrohydroshengmanol-3-O-β-D-galactopyranoside (2), 7,8- didehydrocimigenol-3-O-β-D-galactopyranoside (3), 24-epi-24-O- acetylhydroshengmanol-3-O-β-D-galactopyranoside (4), cimigenol-3-O-β-D- galactopyranoside (5), 25-O-methylcimigenol-3-O-β-D-galactopyranoside (6), 25-O-acetylcimigenol-3-O-β-D-galactopyranoside (7) and 25-O- acetylcimigenol-3-O-β-D-glucopyranoside (8). Genuine aglycones were obtained by the hydrolysis of 1-7 with lactase F[Amano] and of 8 with cellulase T[Amano]4. Acerinol was prepared from 7,8-didehydrocimigenol and showed antilipemic effects.