Seroprevalence to Bartonella quintana among patients at a community clinic in downtown Seattle

Abstract

In 1993, an outbreak of 10 cases of Bartonella quintana bacteremia occurred among homeless, alcoholic, human immunodeficiency virus (HIV)- negative persons in Seattle. To estimate the prevalence of past exposure B. quintana among this population, a serosurvey was conducted in 1994 among patients at a downtown Seattle clinic. Microimmunofluorescent titers to B. quintana in 192 clinic patients were compared with titers in 199 age- and sex-matched Seattle volunteer blood donors. Titers ≥64 were detected in 20% (39/192) of clinic patients compared with 2% (4/199) of blood donors (P < .001). Among clinic patients, alcohol abuse was independently associated in multivariate analysis with titers ≥64 (odds ratio, 3.3; 95% confidence interval, 1.6-6.9). Of the 39 patients with B. quintana titers ≥64, 24 (62%) also had titers ≥64 to Bartonella henselae, indicating serologic cross- reactivity between Bartonella species. These results suggest that a substantial proportion of this indigent, inner-city Seattle population was infected with B. quintana.