Synthesis, characterisation and vasolidation properties of indanone-based chalcones

Abstract

Six indanone-based chalcones were successfully synthesised from 1-indanone and 4-benzaldehyde derivatives via Claisen-Schmidt condensation reaction. The synthesised indanone-based chalcones were characterised by CHN elemental analysis, FTIR spectroscopy and NMR spectroscopy to determine their structures. Vasodilation studies indicated compounds 1b1 and 1-OH showed good vasodilation properties with Rmax value of 38.34 ± 8.90% and 96.68 ±14.77%, respectively. Compound with hydroxyl group shows better effect to the relaxation of the aortic rings.