Preparation and Properties of Fluorescent Labels Coumarin-6/HP-β-CD Complex by Nasal Drug Delivery

Abstract

In order to improve the solubility and dissolution of coumarin-6, coumarin-6/HP-β-CD complex was prepared by freeze-drying. Phase solubility, UV-vis spectroscopy and fourier transformation infrared spectrum results showed that as the concentration of HP-β-CD increased, the soluble coumarin-6 in solution increased and it can be encapsulated to the cavity of HP-β-CD. Then the dissolution result showed that the complex of HP-β-CD can effectively increase the dissolution rate of coumarin-6.