Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tu 4113

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Abstract

A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tu 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.

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Höltzel, A., Kempter, C., Metzger, J. W., Jung, G., Groth, I., Fritz, T., & Fiedler, H. P. (1998). Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tu 4113. Journal of Antibiotics, 51(8), 699–707. https://doi.org/10.7164/antibiotics.51.699

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