Abstract
A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats. © 1981, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
Cite
CITATION STYLE
Albers-Schönberg, G., Joshua, H., Lopez, M. B., Hensens, O. D., Springer, J. P., Chen, J., … Patchett, A. A. (1981). Dihydromevinolin, A potent hypocholesterolemic metabolite produced by aspergillus terreus. Journal of Antibiotics, 34(5), 507–512. https://doi.org/10.7164/antibiotics.34.507
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
