Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats

Abstract

The aim of this work was to study the effect of antimalarial drugs on the bioavailability of 99mTc-MDP in rats. Mefloquine (MQ) and artemisinin (AM) were administered in two treated groups (T) and sorbitol in control group (C) for 7 days. Then, 99mTc-MDP was injected in all groups and %ATI was calculated. A significant increase of %ATI in MQ group, from C to T, occurred in spleen (0.35±0.10 to 0.58±0.13), liver (1.69±0.28 to 3.31±0.07) and blood (0.79±0.17 to 2.09±0.53). The %ATI increased significantly in AM group:femur (2.76±0.59 to 5.98±0.70), liver (1.69±0.28 to 4.59±0.68), lungs (0.29±0.05 to 6.22±0.86), spleen (0.35±0.10 to 0.86±0.15) and blood (0.79±0.17 to 4.65±0.74). A significant decrease of %ATI occurred in MQ group:bladder (0.75±0.07 to 0.26±0.05), stout bowel (2.13±0.34 to 0.66±0.19), pancreas (0.87±0.24 to 0.28±0.18), kidneys (7.00±1.52 to 3.46±0.62), brain (0.27±0.08 to 0.05±0.01) and also in AM group:bladder (0.75±0.07 to 0.30±0.05), stout bowel (2.13±0.34 to 0.36±0.08), muscle (2.04±0.39 to 0.26±0.06), pancreas (0.87±0.24 to 0.46±0.12) and kidneys (7.00±1.52 to 4.35±0.28). These results could be associated to biological effects of antimalarial drugs.