Robust helix formation in a new family of oligoureas based on a constrained bicyclic building block

Abstract

BAC for more: A constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution (see scheme) and in the solid state. A robust H-bond (dotted line) network was found between the carbonyl oxygen atoms (red) and the amino groups (dark blue) within the helix. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.