Study on α-glucosidase inhibitory activity of isolated flavones from genus Artocarpus and their enzyme kinetics

Abstract

Flavonoids are the major compounds associated with diverse bioactivities, especially with α-glucosidase inhibitory activity related to diabetes mellitus. The study reported the α-glucosidase inhibitory activity of seventeen flavonoids isolated from Artocarpus heterophyllus, Artocarpus rigida, and Artocarpus altilis. The results indicated that all flavones possessed an α-glucosidase inhibitory effect, in which compounds 3, 5-7, 9-17 strongly inhibited α-glucosidase enzyme with the IC50 value range from 1.5 to 6.4 μM. Based on their structure-activity relationships, the prenylation patterns at the flavonoid skeleton gave significantly potent inhibitory abilities against α-glucosidase. Further kinetics studies were conducted to determine the inhibition type of these prenylated flavones. This is the first time prenylflavones isolated from genus Artocarpus were reported on the α-glucosidase inhibitory activity and its kinetics. The report suggested that prenylflavones are potential sources for diabetes mellitus treatment.