Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1- piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.
CITATION STYLE
Horton, J. S., Buckley, C. L., & Stokes, A. S. (2013). Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels, 7(1). https://doi.org/10.4161/chan.23006
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