Paramount Role of Solid Dispersion in Enhancement of Solubility

Abstract

One of the favorable strategy to improve the solubility and hence bioavailability of poorly water soluble drugs is the formulation of solid dispersion. It refers to dispersion of an active ingredient in a carrier at solid state which is prepared by solvent evaporation method, melting method, melt solvent method, kneading method, co-grinding method, co-precipitation method, modified solvent evaporation method, spray drying, gel entrapment technique, and co-precipitation with supercritical fluid. On the basis of the carrier used in solid dispersion it is classified as first, second and third generation solid dispersions. As per biopharmaceutical classification system class II drugs are with low solubility and high permeability and are the promising candidates for improvement of bioavailability by solid dispersion. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier, molecular arrangement of drugs in solid dispersions are discussed in this article. © 2011 IGJPS. All rights reserved.