Novel 2',5'-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells

  • Rice A
  • Kerr S
  • Roberts W
  • et al.
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Abstract

2-5A[ppp(A2'p)nA] and related materials accumulate to greater than micromolar concentrations in vaccinia virus-infected HeLa cells and in interferon-treated, vaccinia-infected HeLa, CV1, and L929 cells even when virus replication is not inhibited. A variably complex mixture of authentic 2-5A (n = 2 to 4), nonphosphorylated cores [(A2'p)nA; n = 2 to 5], and additional compounds of unknown structure was observed.

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Rice, A. P., Kerr, S. M., Roberts, W. K., Brown, R. E., & Kerr, I. M. (1985). Novel 2’,5’-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells. Journal of Virology, 56(3), 1041–1044. https://doi.org/10.1128/jvi.56.3.1041-1044.1985

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