Regulation of duplex DNA strand displacement by visible light sensitive bis-peptide nucleic acid.

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Abstract

A novel visible light sensitive azobenzene (AZO) was synthesized and introduced into bis-peptide nucleic acid (bis-PNA), which consists of two homopyrimidine PNA strands, as a linker. Visible light irradiation of the bis-PNA-AZO conjugate induced photoisomerization of the azobenzene moiety from trans to cis. The cis-form of bis-PNA-AZO displaced the complementary duplex DNA more efficiently than the trans-form.

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Sawada, S., Imada, I., Kato, N., & Kaihatsu, K. (2009). Regulation of duplex DNA strand displacement by visible light sensitive bis-peptide nucleic acid. Nucleic Acids Symposium Series (2004), (53), 191–192. https://doi.org/10.1093/nass/nrp096

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