Effect of glycemic control on microalbuminuria development among type 2 diabetes with high-normal albuminuria

15Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

This study was aimed at revealing the factors and the interrelationships between factors on microalbuminuria development among type 2 diabetes (T2D) patients. Between 2004 and 2011, 461 T2D patients with a baseline urine albumin-to-creatinine ratio (UACR) of <30mg/g, and an estimated glomerular filtration rate (eGFR) of >60mL/min were evaluated retrospectively. Sixty-eight (14.8%) subjects had developed microalbuminuria in a mean follow-up of 6.82 years. Statistical analysis had revealed that the higher baseline UACR (10mg/g; sensitivity, 80.9%, specificity, 63.6%; AUC=0.774) and glycohemoglobin level (HbA1c) (8%; sensitivity, 72.1%, specificity, 61.6%; AUC=0.698) were the two independent microalbuminuria risk factors. When considering the risk of microalbuminuria, the data were normalized with respect to subjects with low-normal UACR (<10mg/g) and HbA1c<8%. The adjusted hazard ratio for subjects with low-normal UACR/HbA1c>8%, high-normal UACR/HbA1c<8%, and high-normal UACR/HbA1c >8% were 2.59 (p=0.107), 6.15 (p=0.001), and 16.96 (p<0.001), respectively. It was determined that an increase of HbA1c levels (<8, 8-9, 9-10, >10%) showed a progressively increase of the hazard risk in baseline high-normal UACR group. But the same correlation was not shown in the low-normal UACR group. This study identified the relationships of high-normal albuminuria and glycemic control on microalbuminuria development among T2D patients. Glycemic control is especially beneficial for T2D patients with baseline high-normal UACR in preventing microalbuminuria development. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.

Cite

CITATION STYLE

APA

Chen, W. Z., Hung, C. C., Wen, Y. W., Ning, H. C., Gau, B. R., & Huang, Y. Y. (2014). Effect of glycemic control on microalbuminuria development among type 2 diabetes with high-normal albuminuria. Renal Failure, 36(2), 171–175. https://doi.org/10.3109/0886022X.2013.832312

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free