Notch: Of mice and men?

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Abstract

A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.1 In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.2 Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?

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Malinge, S., & Crispino, J. (2010, December 16). Notch: Of mice and men? Blood. American Society of Hematology. https://doi.org/10.1182/blood-2010-09-308395

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