The comparison on antihyperglycemic activity between gedong gincu mango leaf (Mangifera indica var. gedong gincu) and metformin in streptozotocin-induced diabetic rats

Abstract

Pharmacologic treatment is one of important modalities in the comprehensive management in type 2 diabetes mellitus, whereas metformin is the first line drug of choice in initiating oral antihyperglycemic agent. Mangiferin, quersetin, tannins, and flavonoid have blood-glucose lowering properties. They are available in mango leaf. Gedong gincu mango is widely available in Cirebon, West Jawa, Indonesia, but the study enrolling its leaf in antihyperglycemic effect is not provided yet. This study was aimed to compare antihyperglycemic activity between gedong gincu mango leaf (Mangifera indica var. gedong gincu) and metformin on streptozotocin-induced diabetic rats. This study was experimental research with pre- and post-test control group design enrolling 30 wistar streptozotocin-induced rats divided into 5 groups of treatment consists of 1 negative control group, and 4 positive control group using metformin 9mg/200gr and 3 groups given gedong gincu mango leaf extract with doses of 150 (P1), 300 (P2) and 600 (P3) mg/200 gr for 7 days. There is significant decrease in blood glucose level in P1, P2, and P3 (96.24mg/dl, 116.62 mg/dl, and 136.21mg/dl). We concluded that gedong gincu mango leaf has antihyperglycemic activity in dose-dependent response. The 600 mg/200g of it is not inferior to 9mg/200g of metformin in antihyperglycemic activity.