Biokimia Mycobacterium Tuberculosis yang Diberi Perlakuan Obat Anti TB Isoniazid

Abstract

Mycobacterium tuberculosis exposed to Isoniazid experienced drug resistance due to morphological and selection factors, with Isoniazid concentrations of 0.5 μg / ml with a contact time of 24 hours, 48 hours, 72 hours, 96 hours, the results obtained in testing for NaCl 5% Kruskal wallis obtained sig 0.005 results there is a treatment effect on growth While in the semi-quantitative catalase test, a sig value of 0.007 was obtained with p 0.01 so it can be concluded that there is a significant influence between the duration of isoniazid exposure. resistance occurs due to the selection of strains that are resistant to treatment during the therapy process at 96 hours exposure with a percentage of 2%. In the exposure process it can be concluded that it will change the resistance to 5% NaCl, changes in Catalase test results and also causes strain selection that is resistant to isoniazid 0.5 µg / ml.