The role of ascorbic acid in the mosaic of coronary heart disease: Lipid metabolism and antioxidant functions

Abstract

Ascorbic acid (AA) is purported to have a preventative role in coronary heart disease (CHD) incidence. Studies in animal models support an interaction of AA in lipid metabolism, while results from epidemiological and supplementation trials conducted in humans are inconsistent. However, AA may mediate its protective action against CHD via its function as an antioxidant, inhibiting lipid peroxidation and regenerating α-tocopherol. Although AA can exert potentially beneficial effects, excessive AA administration can lead to damaging effects via interactions with transition metals, such as iron and copper.