Thiacycloalkynes for copper-free click chemistry

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Abstract

The heteroatom helps! The introduction of an endocyclic sulfur atom enables fine-tuning of the reactivity and stability of thiacycloalkynes for copper-free click chemistry. The stabilizing effect of the endocyclic sulfur atom allows the use of highly activated seven-membered rings as reagents for bioorthogonal copper-free click chemistry. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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De Almeida, G., Sletten, E. M., Nakamura, H., Palaniappan, K. K., & Bertozzi, C. R. (2012). Thiacycloalkynes for copper-free click chemistry. Angewandte Chemie - International Edition, 51(10), 2443–2447. https://doi.org/10.1002/anie.201106325

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