Clinical effects of Lactobacillus acidophilus combined with mosapride in treatment of gastrointestinal dysfunction after craniocerebral injury

Abstract

BACKGROUND Most patients with severe craniocerebral injury have gastrointestinal motility deficiency. When the body is exposed to external mechanical trauma, infection, vomiting, and gastric content reflux tend to occur, which causes early gastrointestinal dysfunction, affects nutrient intake, aggravates brain edema, delays wound healing, and is not conducive to the prognosis of patients. Mosapride is a commonly used gastrointestinal motility agent, which can improve gastrointestinal motility and speed up gastric emptying. Lactobacillus acidophilus can regulate the intestinal flora, protect the intestinal mucosal barrier, maintain intestinal balance, and relieve gastric motility. The purpose of this study was to investigate the effects of Lactobacillus acidophilus combined with mosapride treatment on the time to reach enteral nutrition standards, intestinal flora, rehabilitation process, and other aspects of patients with gastrointestinal dysfunction after craniocerebral injury, and to evaluate its clinical effects. AIM To observe the clinical effects of Lactobacillus acidophilus combined with mosapride in the treatment of gastrointestinal dysfunction after craniocerebral injury. METHODS A total of 92 patients with gastrointestinal dysfunction after craniocerebral injury at our hospital from February 2018 to February 2021 were selected and divided into a study group and a control group at a ratio of 1:1 using a random number table, with 46 cases in each group. On the basis of conventional treatment, the control group was given mosapride, and the study group was given Lactobacillus acidophilus combined with mosapride for 1 wk. The clinical efficacy, time to reach enteral nutrition standards, recovery progress, 28-d mortality rate, gastric motility indexes [intra-abdominal pressure (IAP) and residual gastric volume (GRA)], and intestinal motility before treatment and after 3 d and 1 wk of treatment were compared between the two groups. Intestinal barrier function indexes [D-lactic acid (D-LA) and diamine oxidase (DAO)] and intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus, and Enterobacter) were also compared. RESULTS The total effective rate of the study group was higher than that of the control group (93.48% vs 78.26%, P < 0.05). The time to reach enteral nutrition standards, time to mechanical ventilation, and the length of ICU stay in the study group were shorter than those of the control group (P < 0.05). There was no significant difference in the 28-d mortality rate between the two groups (P > 0.05). The APACHE II and SOFA scores of the study group were lower than those of the control group after 3 d and 1 wk of treatment, and the Glasgow Coma scale scores were higher than those of the control group (P < 0.05). The levels of IAP, GRA, D-LA, and DAO in the study group were lower than those of the control group after 3 d and 1 wk of treatment (P < 0.05). The numbers of Bifidobacterium and Lactobacillus in the study group were more than those of the control group after 3 d and 1 wk of treatment, and the numbers of Enterococcus and Enterobacter were less than those of the control group (P < 0.05). CONCLUSION Lactobacillus acidophilus and mosapride are effective in treating gastrointestinal dysfunction after craniocerebral injury. They can shorten the time to reach enteral nutrition standards, adjust the intestinal flora, protect the intestinal mucosal barrier, promote the recovery of the gastrointestinal tract and nerve function, and accelerate the recovery process of patients.