Introduction: The earlier treat stage 3 ROP is more likely to achieve better outcomes. Primary Purpose: To study the unfavorable outcomes and regression after pre-early treatment for ROP. Secondary Purpose: To evaluate the progression and recurrence of ROP requiring retreat-ment after pre-early treatment for ROP. Patients and Methods: The data were retrieved retrospectively from the medical records of all infants who were screened and treated for ROP from January 2009 to January 2014 at a tertiary care facility. The outcomes measured the following: 1. unfavorable outcomes; 2. regression of ROP; 3. progression of ROP and 4. recurrence of ROP requiring retreatment. We treated all stage 3 ROP in any zone, with or without plus. The study also compared the outcomes between the pre-ETROP and the ETROP subgroups. Results: There were 91 eyes with stage 3 ROP. Of the total of 91 eyes, there were 63 eyes with the pre-ETROP group and 28 eyes of the ETROP group. The unfavorable outcomes after treatment occur 6 eyes from 28 eyes (21.43%) in the ETROP group but no unfavorable outcomes in the pre-ETROP group (P=0.001). The pre-ETROP group who were treated with laser LIO alone had 100% regression, while the ETROP group who were treated with LIO (26 eyes) had 88.46% regression. There were 2 eyes of this group who were treated with a combination of LIO and IVT Bevacizumab. Both of them did not have regression. The recurrence of ROP requiring retreatment occurred in 2 eyes (7.14%) of the ETROP group, but no recurrence in the pre-ETROP group (P=0.092). The progression after treatment occurred in 3 eyes (10.71%) in the ETROP group, but no progression in the pre-ETROP group (P=0.027). Conclusion: The pre-ETROP treatment is useful for reducing unfavorable outcomes and increasing the regression of ROP. Further, the treatment can reduce the recurrence of neovascularization and progression after treatment.
CITATION STYLE
Titawattanakul, Y., Kulvichit, K., Varadisai, A., & Mavichak, A. (2020). Outcomes of pre-early treatment for retinopathy of prematurity (Pre-etrop). Clinical Ophthalmology, 14, 3393–3397. https://doi.org/10.2147/OPTH.S268997
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