Profile of organophosphate poising cases, clinical outcome and factors associated with outcome among them in a tertiary care teaching hospital

Abstract

Background: Poisoning by Organophosphorus poisoning is still one of the most common cause of poisoning and is associated with significant morbidity and mortality. With addition of new compounds and changing patient profile, periodic studies exploring the factors affecting treatment outcomes are vital in providing effective management.Methods: The current study was conducted with an objective of assessing the profile of organophosphate poisoning and factors affecting the outcome in a tertiary care hospital. The current study was a prospective observational study, conducted in the emergency department of medical inpatient ward and ICU of NRI medical college and Hospital, Andhra Pradesh between June 2015 to July 2016. Patients >18 years admitted to emergency department organophosphorus or carbamate poisoning were included in the study.Results: One hundred patients presented to the hospital between June 2015 to July 2016 of which 71% were males. About 59% of the patients belonged to 21-30-year group and 67% of them reached our hospital in <6 hours. Grade 1 poisoning was observed in 45% of patients, a dose of <500 units of pseudo cholinesterase was given to 40% of them. A Glasgow Coma Score >10 was found in 75% of the patients and the overall mortality of OP poisoning was 17%.Conclusions: OP poisoning is more common among younger population, below 30 years with male preponderance. Favourable outcome determinants were younger age, female gender, being admitted to the hospital before 6 hours of OP consumption.