Carrier mediated protein and peptide stabilization

Abstract

Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the protein and peptides into a particulate carrier can protect it against degradation in vitro and in vivo, the release can be controlled, and it also offers possibilities for targeting. This review has focused on a wide range of bioactive carriers used in protein stabilization during long time storage. Bioactive carriers can protect the bioactives from degradation, resulting in increased bioavailability of protein. © 2010 Informa Healthcare USA, Inc.