Enantioselective intramolecular aldol reaction mediated by a combination of L-amino acid and Brønsted acid to construct a bicyclic enedione containing a 7-membered ring

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Abstract

The enantioselectivity of the intramolecular asymmetric aldol reaction of 1,3-cycloheptanedione bearing a C-2 methyl substituent, mediated by a series of combinations of L-amino acid and Brønsted acid, was examined in detail. © 2007 Pharmaceutical Society of Japan.

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Nagamine, T., Inomata, K., & Endo, Y. (2007). Enantioselective intramolecular aldol reaction mediated by a combination of L-amino acid and Brønsted acid to construct a bicyclic enedione containing a 7-membered ring. Chemical and Pharmaceutical Bulletin, 55(12), 1710–1712. https://doi.org/10.1248/cpb.55.1710

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