Coherence transfer delay optimisation in PSYCOSY experiments

Abstract

PSYCOSY is an f1 broadband homonuclear decoupled version of the COSY nuclear magnetic resonance pulse sequence. Here, we investigate by a combination of experimental measurements, spatially distributed spin dynamics simulations, and analytical predictions the coherence evolution delay necessary in PSYCOSY experiments to ensure intensity discrimination in favour of the correlations typically arising from short range (nJ, n ≤ 3) 1H–1H couplings and show that, in general, a coherence evolution delay of around 35 ms is optimum.