A short stereoselective synthesis of (-)-chloramphenicol and (+)-thiamphenicol

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Abstract

A common strategy for the synthesis of (-)-chloramphenicol and (+)-thiamphenicol is described. These antibiotics have been synthesized from commercially available 4-nitrobenzaldehyde and 4-(methylthio)benzaldehyde in three and four steps, respectively. © 2004 Elsevier Ltd. All rights reserved.

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Bhaskar, G., Satish Kumar, V., & Venkateswara Rao, B. (2004). A short stereoselective synthesis of (-)-chloramphenicol and (+)-thiamphenicol. Tetrahedron Asymmetry, 15(8), 1279–1283. https://doi.org/10.1016/j.tetasy.2004.03.007

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