On the history of nuclear matrix manifestation

Abstract

The nonchromatin proteinous residue of the cell nucleus was revealed in our laboratory as early as in 1948 and then identified by light and electron microscopy as residual nucleoli, intranuclear network and nuclear envelope before 1960. This structure termed afterwards as "nuclear residue", "nuclear skeleton", "nuclear cage", "nuclear carcass" etc., was much later (in 1974) isolated, studied and entitled as "nuclear matrix" by Berezney and Coffey, to whom the discovery of this residual structure is often wronly ascribed. The real history of nuclear matrix manifestation is reported in this paper.