Monoepitopic anti-FVIII T-cell response

Abstract

In this issue of Blood, Ettinger et al show that the T-cell response to therapeutic factor VIII (FVIII) in a patient with severe hemophilia A due to a multi-exon F8 deletion was oligoclonal and directed against a single epitope located in the C2 domain of the molecule. They further demonstrated that the HLA-DRB1∗01:01-restricted T-cell epitope was recognized by the T cells of 2 other hemophilia A patients with the A2201P missense mutation.1