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Synthesis of 4,4-Difluoro-1 H -pyrazole Derivatives

Synlett (2015) 26(1) 51-54
DOI: 10.1055/s-0034-1378915
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Abstract

Fluorination of 3,5-diarylpyrazole substrates by SelectfluorTM in acetonitrile gave 4,4-difluoro-1H-pyrazoles in addition to 4-fluoropyrazole derivatives. The structure of this new class of fluorinated heterocycle was established by X-ray crystallography.

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Breen, J. R., Sandford, G., Patel, B., & Fray, J. (2015). Synthesis of 4,4-Difluoro-1 H -pyrazole Derivatives. Synlett, 26(1), 51–54. https://doi.org/10.1055/s-0034-1378915

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