Nuclei Detection and Classification System Based On Speeded Up Robust Feature (SURF)

Abstract

Tumors contain a high degree of cellular heterogeneity. Various type of cells infiltrate the organs rapidly due to uncontrollable cell division and the evolution of those cells. The heterogeneous cell type and its quantity in infiltrated organs determine the level maglinancy of the tumor. Therefore, the analysis of those cells through their nuclei is needed for better understanding of tumor and also specify its proper treatment. In this paper, Speeded Up Robust Feature (SURF) is implemented to build a system that can detect the centroid position of nuclei on histopathology image of colon cancer. Feature extraction of each nuclei is also generated by system to classify the nuclei into two types, inflammatory nuclei and non-inflammatory nuclei. There are three classifiers that are used to classify the nuclei as performance comparison, those are k-Nearest Neighbor (k-NN), Random Forest (RF), and State Vector Machine (SVM). Based on the experimental result, the highest F1 score for nuclei detection is 0.722 with Determinant of Hessian (DoH) thresholding = 50 as parameter. For classification of nuclei, Random Forest classifier produces F1 score of 0.527, it is the highest score as compared to the other classifier.