Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. Ten years experience in Denmark

Abstract

Objectives. To evaluate survival and functional outcome in patients treated by pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension in Denmark. Design. Follow-up of the first 50 patients operated at Aarhus University Hospital, Denmark. Results. Fifty patients underwent PEA in the period from 1994 to mid 2004. Prior to surgery all patients were in World Health Organization (WHO) function class III (n = 33) or IV (n = 17). The mean pulmonary artery pressure was 50 mmHg (range 25-76), cardiac index 1.8 l min-1 m-2 (range 0.8-2.8) and pulmonary vascular resistance 819 dyn s cm-5 (range 241-3 067). In-hospital mortality was 12/50 (24%). Surgical mortality was highest in the early period. Since year 2000 in-hospital deaths occurred in only 2 among 23 patients (9%). Leading causes of death were persistent pulmonary hypertension and bleeding. Three patients died during long-term follow-up with a median observation time of 3 years. The overall 5 year survival rate was 74%. At 3 months follow-up 90% of the patients (34/38) had improved one or more WHO functional classes and the systolic pulmonary artery pressure estimated by Doppler echocardiography had decreased from 80 mmHg (range 49-115) to 43 mmHg (range 14-95). Conclusion. Pulmonary endarterectomy has been successfully implemented in Denmark. The perioperative mortality was reduced over time to 9% during the past 5 years. Functional outcome and long-term survival were excellent stressing the importance of surgical treatment for chronic thromboembolic pulmonary hypertension. © 2006 Taylor & Francis.