Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII

Abstract

Background: Low density lipoprotein receptor (LDLR) mediates clearance of blood coagulation factor VIII (FVIII). Results: The region of complement-type repeats 2-5 in LDLR was identified as the binding site for FVIII and for -2-macroglobulin receptor-associated protein (RAP). Conclusion: Binding sites of LDLR for FVIII, and also for RAP, were characterized. Significance: This provides new data on LDLR structure and function and on FVIII catabolism. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.