Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections

Abstract

Male Sprague-Dawley rate were trained in an inhibitory avoidance task and injected with saline or fluoxetine (15.0 mg/kg i.p.) immediately after training. Fluoxetine significantly facilitated retention assessed on a retention test 48 h later. In contrast, posttraining intra-amygdala injections of fluoxetine (1.0, 3.0, or 10.0 µg) did not modify retention of the inhibitory avoidance task. The findings suggest that the amygdala serotonergic system is not involved in the modulation of memory in this task. © 1992, Psychonomic Society, Inc.. All rights reserved.