Bioactive components from Ficus glomerata

Abstract

Different parts of the plant Ficus glomerata Roxob was extracted with water and organic solvents. The effects of these extracts on blood sugar level of streptozotocin induced diabetic rats were studied. The pet ether extract of the stem bark of the plant reduced the blood sugar level significantly. Extracts from fruit and latex of the plant did not have any significant effect on blood sugar level of these diabetic rats. The pet ether extract of the stem bark completely inhibited the enzymes glucose-6-phosphatase and arginase and activated the enzyme glucose-6-phosphate dehydrogenase from rat liver. Extracts from fruit and latex inhibited only glucose-6-phosphatase but not arginase from rat liver. A number of components from pet ether extract of the stem bark were isolated and purified. The effect of these purified components on pure enzyme glucose-6-phosphate dehydrogenase were investigated. The chemical characterisation of some of these components were carried out. © 1994 IUPAC