The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis

Abstract

Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients. Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator. Results: Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], P =.03; I2 = 51%, P =.01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], P =.009; I2 = 14%, P =.32) and severe COVID-19 (RR 2.89 [0.98, 8.46], P =.05; I2 = 57%, P =.04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], P