Clinical Management of Boric Acid Ingestion: Pharmacokinetic Assessment of Efficacy of Hemodialysis for Treatment of Acute Bo ric Acid Poisoning

Abstract

Seven hours after suicidal ingestion of about 21 g of boric acid, a 26-year-old female admitted to our hospital in a state of slightly impaired consciousne ss, with frequent vomiting, shivering, fever and skin flush. Immediately, gastric lavage, followed by administration of activated charcoal and laxative (MgS04), was performed. In order to ensure her urination, fluid infusion therapy was conducted with the aid of diuretics (furosemide). Since the serum concentrations of boric a cid was very high, hemodialysis was carried out twice during the first 39 h. She responded well to the above mentioned treatment and was discharged 12 d post-admiss ion without any sequelae. © 1992, The Pharmaceutical Society of Japan. All rights reserved.