(1S)-(-)- N -Trifluoromethylthio-2,10-camphorsultam and its derivatives: Easily available, optically pure reagents for asymmetric trifluoromethylthiolation

Abstract

A family of easily scalable, shelf-stable, optically pure reagents (1S)-(-)-N-trifluoromethylthio-2,10-camphorsultam 1a-c was successfully developed. In particular, compound 1c was shown to be an efficient reagent that is capable of transferring chirality to other prochiral nucleophiles such as β-ketoesters, oxindoles and benzofuranones with good to excellent enantioselectivities.