Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period by about 5years. Most of them are nonresorbable, and these implants can lead to many complications that are in some cases life-threatening. Electrospun nanofibers of various polymers have been used as tissue scaffolds and have been explored extensively in the last decade, due to their low cost and good biocompatibility. Their architecture mimics the natural extracellular matrix. We tested a biodegradable polyester poly-ε-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure-reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model showed promising results. © 2014 Plencner et al. This work is published by Dove Medical Press Limited.
Plencner, M., East, B., Tonar, Z., Otáhal, M., Prosecká, E., Rampichová, M., … Amler, E. (2014). Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation. International Journal of Nanomedicine, 9(1), 3263–3277. https://doi.org/10.2147/IJN.S63095