Regioselective three-component synthesis of tetrahydrobenzimidazo[2,1-b] quinazolin-1(2H)-ones

Abstract

Reaction between 2-aminobenzimidazole 1, dimedone 2 and aldehydes 3 in ethanol afforded tetracyclic 12-aryl-3,3-dimethyl-3,4,5,12- tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-ones 4a-g in good yields. The reactions were highly regioselective, what was established by nmr measurements.