A Four-Component Domino Reaction: An Eco-Compatible Access to Diversified Imidazo[2,1-b][1,3]thiazin-5-ones

Abstract

A multicomponent domino reaction of thiourea, alkyl propiolates, aldehydes, and isocyanides has been established, providing direct access to 2-aryl-5H-imidazo[2,1-b][1,3]thiazin-5-one scaffolds. The simplicity of execution, readily available substrates, cheap reagents, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more efficient and worthy of further attention.