Synthethic gene transfer vectors

Abstract

Gene transfer into mammalian cells is a prerequisite to gene therapy. Designed synthetic DNA carriers could be attractive alternatives to presently used viral vectors. Toward this end, lipopolyamines have been developed, which spontaneously condense DNA and coat it with a cationic lipid layer. The resulting nucleolipidic particles transfect efficiently various eukaryotic cells. © 1994, Walter de Gruyter. All rights reserved.