Silica functionalized sulfonic acid catalyzed one-pot synthesis of 4,5,8a-triarylhex-ahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-diones under liquid phase catalysis

Abstract

SiO2-SO3H catalyzed one-pot synthesis of 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine- 2,7(1H,3H)-diones (4a-k) is reported under liquid phase catalysis. The catalyst is easily prepared, highly stable, very simple to handle and recycled for five times without loss of significant activity. © 2010 Sociedade Brasileira de Química.