(+)-Bornyl piperate, a new monoterpene ester from Piper aff. pedicellatum roots

Abstract

A new monoterpene ester, (+)-bornyl piperate was isolated from the underground roots of Piper aff. pedicellatum and its structure was elucidated on the basis of spectroscopic evidence and confirmed by X-ray analysis. The compound crystallizes in the triclinic space group P1 with a=7.3232(4) Å, b=11.4705(7) Å, c=23.2520(14)Å, V=1943.6(2)Å3. This compound showed an antituberculosis activity against Mycobacterium tuberculosis (H37Ra strain) with the minimum inhibitor concentration (MIC) of 25 μg/ml. © 2004 Pharmaceutical Society of Japan.