A novel way of synthesis of 1,3,5-trisubstituted-2-thioxoimidazolidinones

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Abstract

Title compounds were prepared by 1,4-nucleophilic addition of 2-thioxoimidazolidin-4-ones to 3-aryl-2-cyano acrylates, followed by alkylation. Reaction yield are much better than those obtained in case of Knoevenagel-type condensation.

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Brandao, S. S. F., Andrade, A. M. C., Pereira, D. T. M., Barbosa Filho, J. M., Lima, M. C. A., Galdino, S. L., … Barbe, J. (2004). A novel way of synthesis of 1,3,5-trisubstituted-2-thioxoimidazolidinones. Heterocyclic Communications, 10(1), 9–14. https://doi.org/10.1515/hc.2004.10.1.9

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