Comparison of novel synthetic peptide-based DETECT-RUBELLA enzyme immunoassays with enzygnost and IMx for detection of rubella-specific immunoglobulin G

Abstract

Enzyme immunoassays (EIAs) using synthetic peptides SP-E1 and SP-E1E2 (DETECT-RUBELLA [BioChem]) were compared with two viral lysate-based EIAs (Enzygnost [Behring] and IMx [Abbott]) for the detection of rubella virus- specific immunoglobulin G antibodies. Sensitivities of 94.7, 100, 98.6, and 100% and specificities of 100, 97.4, 100, and 73.7% were found for the SP- E1, SP-E1E2, Enzygnost, and IMx EIAs, respectively.