Engineering Trojan-horse bacteria to fight cancer

Abstract

In this issue of Blood, Massa et al demonstrated that tumor-tropic bacteria engineered to express specific cancer-related antibodies can recognize and specifically destroy the malignant cells by infecting them with toxic cargo. The findings provide an essential step in establishing the novel approach of enlisting engineered bacteria that speak cancer's language to outsmart and defeat cancer. Copyright © 2011 by The American Society of Hematology; all rights reserved.