Epidemiology and Clinical Forms of Primary Hyperparathyroidism: A Review

Abstract

Primary hyperparathyroidism (PHPT) is a disease caused by overactive parathyroid glands with consequent hypercalcemia. However, its presentation is variable, with patients demonstrating a range from normocalcemia to severe hypercalcemic PHPT. The present study aims to perform a literature review on the epidemiology and the clinical forms of PHPT using information published in the PubMed and Cochrane databases. It describes data about prevalence, etiology, diagnosis, classic and non-classic manifestations, providing updated information on classical hypercalcemic hyperthyroidism, in addition to its normocalcemic variant.