Abstract
Fluoroquinolone efflux was studied in 47 Staphylococcus aureus clinical strains with MICs of ciprofloxacin (CFX) of ≤2 μg/ml. Forty-three strains were wild type for gyrA, gyrB, and grlA quinolone resistance-determining regions and for norA and its promoter region. Forty of these strains (MICs of CFX, 0.1 to 0.2 μg/ml) did not show efflux of fluoroquinolones. Three strains (MICs of CFX, 1 to 2 μg/ml) showed efflux. These results suggest that efflux can appear in S. aureus clinical strains in the absence of mutations in norA and its promoter.
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CITATION STYLE
Muñoz-Bellido, J. L., Manzanares, M. A. A., Andrés, J. A. M., Zufiaurre, M. N. G., Ortiz, G., Hernández, M. S., & García-Rodríguez, J. A. (1999). Efflux pump-mediated quinolone resistance in staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA. Antimicrobial Agents and Chemotherapy, 43(2), 354–356. https://doi.org/10.1128/aac.43.2.354
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