In-vitro Anticancer and Antioxidant Activity of Green Coffee Beans Extract

Abstract

The main objective of this article is to analyze the efficacy of polyphonic compounds, especially Chlorogenic Acid in anti-obesity and anticancer. Overweight and obesity became severe global health issues in all sex and age groups respectively according to WHO, this is the significant risk factors for several chronic illnesses this is increasing from recent decades, due to lifestyle changes intake of food lack of proper healthcare particularly in urban communities. According to the India Council of Medical Research (ICMR), more than 1300 Indians die every day due to cancer, especially Basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma are primary skin cancers. This research aims to help anti-obese and anticancer by providing health benefits of green Coffee. The ethnobotanical study proved that green coffee beans of Coffee Robusta variety have significant medicinal properties, which are essential for the human diet. In vitro results showed that high free radical scavenging activity with IC50 towards DPPH 30.99µg/mL ABTS0.83 µg/mL, Alpha-amylase 31.75 µg/mL, MTT assay 101.26 µg/mL and Anti-obesity activity 33.34 µg/mL respectively. In conclusion, more in vivo and in vitro experimental studies are required to understand the full use of the extract in the prevention of lethal diseases.